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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Ulinastatin
supplement:
Arachidonate
Research Papers that Mention the Interaction
“Thus, ulinastatin inhibits arachidonate PHS metabolism by inhibiting new induction of PHS-2 at the mRNA level, which is a novel pharmacologic action of this substance.”
Ulinastatin, an elastase inhibitor, inhibits the increased mRNA expression of prostaglandin H2 synthase-type 2 in Kawasaki disease.“It was newly confirmed that the release of 6-keto-PGF1 alpha, thromboxane B2 and leukotriene B4, arachidonate cascade metabolites and chemical mediators associated with endotoxin-induced shock, were significantly (p < 0.01 and p < 0.05) decreased by ulinastatin in the same way as methylprednisolone.”
A therapeutic effect of ulinastatin on endotoxin-induced shock in dogs--comparison with methylprednisolone.
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