Possible Interaction: Ubiquinone and Vitamin E

“However, simultaneous supplementation with vitamin E resulted in lower plasma Q10 levels.”

“Reduced coenzyme Q can prevent lipid peroxidation chain reaction by itself or by reducing other antioxidants such as alpha-tocopherol and ascorbate.”

“There is substantial evidence that CoQ 10 can act in concert with alphatocopherol as an antioxidant within mitochondria.”

“We conclude that ubiquinonols (ubisemiquinones) reduce vitamin E through electron transport.”

“ CoQ10 supplementation in combination with vitamin E significantly improved in sex hormone-binding globulin (SHBG) levels compared with other groups (P = 0.008).”

“ Co-Q10 and vitamin E (alone or in combination) had significant effects on non-HDL-C (p = 0.004), atherogenic Index of Plasma (AIP) (p = <0.001) and lipid accumulation product (LAP) (p <0.001) and SBP (p = 0.005).”

“However, co-administration of CoQ10 and vitamin E resulted in a significant decrease in serum total cholesterol levels (9.92 [15.11, 4.74]).”

“Similarly, the δ-tocopherol concentration correlated positively with γ-tocopherol, α-tocopherol, lutein, Q10 , δ-CEHC, and γ-CEHC concentrations, respectively.”

“Concentrations of CoQ10-TOTAL ubiquinone + ubiquinol ) and α-tocopherol were significantly increased and the oxidative stress was decreased.”

“The level of plasma coenzyme Q10 was significantly positively correlated with vitamin E (P = 0.008) and antioxidant enzymes activities (P < 0.05) and was negatively correlated with TNF-α (P = 0.034) and IL-6 (P = 0.027) after coenzyme Q10 supplementation.”

“Treatment attempts with high-dose intravenous steroids and coenzyme Q10 combined with vitamin E were ineffective.”