Possible Interaction: Ubiquinone and Simvastatin

“ Simvastatin or low density lipoprotein apheresis decreased serum CoQ10 concentrations along with decreasing serum cholesterol.”

“This study demonstrates that simvastatin lowers both LDL-C and apo B plasma levels together with the plasma and platelet levels of CoQ10 , and that CoQ10 therapy prevents both plasma and platelet CoQ10 decrease, without affecting the cholesterol lowering effect of simvastatin.”

“ Simvastatin pre-treatment resulted in a significant decrease in myocardial ubiquinone.”

“Coadministration of CoQ with simvastatin impairs mitophagy and cardioprotection.”

“Co-treatment with CoQ10 appears to prevent the reduction in GLUT4 protein levels caused by simvastatin.”

“In strong contrast, simvastatin stimulated these enzymes dramatically, and reduced coenzyme Q10 levels in liver and heart.”

“ Simvastatin , a commonly used cholesterol‐lowering drug, inhibits the mevalonate pathway involved in the synthesis of the mitochondrial electron carrier coenzyme Q10 ( CoQ10 ), as well as other bioenergetics substrates.”

“In HepG2 cells, simvastatin decreased mitochondrial CoQ10 levels, and at higher concentrations was associated with a moderately higher degree of cell death, increased DNA oxidative damage and a reduction in ATP synthesis.”

“Normalization of plasma nitric oxide concentrations was achieved only with combination of coenzyme Q10 and simvastatin.”

“ Simvastatin and other HMG‐CoA reductase inhibitors have been documented to lower serum concentrations of CoQ10.”