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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Ubiquinone
drug:
Pravastatin
Research Papers that Mention the Interaction
“A dose-related significant decline of the total serum level of coenzyme Q10 was found in the pravastatin group from 1.27 +/- 0.34 at baseline to 1.02 +/- 0.31 mmol/l at the end of the study period (mean +/- S.D.), P < 0.01.”
Dose-related decrease of serum coenzyme Q10 during treatment with HMG-CoA reductase inhibitors.“In contrast, the 6 months therapy with pravastatin in combination with ubiquinone Q10 (60 mg daily) sharply decreased the LDL initial lipoperoxides level whereas during treatment with cerivastatin in combination with probucol (250 mg daily) the LDL lipoperoxides concentration was maintained on an invariable level.”
“This study confirms that pravastatin lowers plasma CoQ10 concentrations, but this does not appear to predict the risk of recurrent CVD events.”
“ Pravastatin treatment (n = 6) decreased LDL cholesterol (-27%), lathosterol (-46%), and ubiquinone (-29%).”
“Here, we hypothesized that these diabetogenic effects of pravastatin could be counteracted by treatment with the antioxidant coenzyme Q 10 (CoQ 10), an intermediate generated in the cholesterol synthesis pathway.”
Coenzyme Q10 protects against β‐cell toxicity induced by pravastatin treatment of hypercholesterolemia
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