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Last Updated: 2 years ago

Possible Interaction: Ubiquinone and Doxorubicin Hydrochloride

Research Papers that Mention the Interaction

It appears that levels of coenzyme Q10 are decreased during therapy with HMG-CoA reductase inhibitors, gemfibrozil, Adriamycin , and certain beta blockers.
The Journal of cardiovascular nursing  •  2002  |  View Paper
The findings of ECG and the myocardial tissue examined by the electron microscope showed the effectiveness of the injection of CoQ10 to prevent the cardiotoxicity caused by ADR.
Gan no rinsho. Japan journal of cancer clinics  •  1984  |  View Paper
Adriamycin and the reference inhibitor of the functionality of CoQ 10 -enzymes at the same concentration gave the same inhibition of biosynthesis.
Biochemical and biophysical research communications  •  1977  |  View Paper
CoQ10 supplementation prevents electrocardiographic (ECG) changes in patients taking doxorubicin and has a positive effect on heart function during anthracycline chemotherapy.
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego  •  2021  |  View Paper
The cardiotoxicity of adriamycin , used in treatment modalities of cancer, is significantly reduced by CoQ10 , apparently because the side-effects of adriamycin include inhibition of mitochondrial CoQ10 enzymes.
Drugs under experimental and clinical research  •  1985  |  View Paper
Further, the QRS voltage was also significantly decreased in patients treated with adriamycin alone, but was not decreased in patients treated with adriamycin plus coenzyme Q10.
These findings suggest that some electrocardiographic changes due to adriamycin may be prevented by coenzyme Q10.
This Suggests that coenzyme Q10 may reduce negative inotropic action induced by adriamycin.
Gan to kagaku ryoho. Cancer & chemotherapy  •  1984  |  View Paper
The continued daily oral administration of 50 mg of CoQ10 beginning with the first dose of ADM resulted in a decreased incidence of cardiac dysfunction, and a gradual increase in STI occurred in only two of eight patients receiving 200-400 mg/m2 of ADM.
Cancer treatment reports  •  1978  |  View Paper
DOXO administration also leads to several histological and ultrastructure alterations including cardiomyocyte degeneration and intense intracelullar autophagosomes, all minimized by Q10 treatment.
Cardiovascular Toxicology  •  2019  |  View Paper
However, Q10 effectively protected cardiomyocytes and ameliorated fibrosis and cell death induced by doxorubicin.
Environmental toxicology  •  2017  |  View Paper
Concomitant administration of CoQ10 with DOX significantly restored testicular oxidative stress parameters and the distorted histopathological picture, reduced the up-regulation of caspase 3 caused by DOX, and increased P-gp expression.
Environmental toxicology and pharmacology  •  2014  |  View Paper
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