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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Ubiquinone
Research Papers that Mention the Interaction
“It appears that levels of coenzyme Q10 are decreased during therapy with HMG-CoA reductase inhibitors, gemfibrozil, Adriamycin , and certain beta blockers.”
Coenzyme Q10 and cardiovascular disease: a review.“The findings of ECG and the myocardial tissue examined by the electron microscope showed the effectiveness of the injection of CoQ10 to prevent the cardiotoxicity caused by ADR.”
“ Adriamycin and the reference inhibitor of the functionality of CoQ 10 -enzymes at the same concentration gave the same inhibition of biosynthesis.”
“ CoQ10 supplementation prevents electrocardiographic (ECG) changes in patients taking doxorubicin and has a positive effect on heart function during anthracycline chemotherapy.”
“The cardiotoxicity of adriamycin , used in treatment modalities of cancer, is significantly reduced by CoQ10 , apparently because the side-effects of adriamycin include inhibition of mitochondrial CoQ10 enzymes.”
“Further, the QRS voltage was also significantly decreased in patients treated with adriamycin alone, but was not decreased in patients treated with adriamycin plus coenzyme Q10.”
“These findings suggest that some electrocardiographic changes due to adriamycin may be prevented by coenzyme Q10.”
“This Suggests that coenzyme Q10 may reduce negative inotropic action induced by adriamycin.”
“The continued daily oral administration of 50 mg of CoQ10 beginning with the first dose of ADM resulted in a decreased incidence of cardiac dysfunction, and a gradual increase in STI occurred in only two of eight patients receiving 200-400 mg/m2 of ADM.”
“ DOXO administration also leads to several histological and ultrastructure alterations including cardiomyocyte degeneration and intense intracelullar autophagosomes, all minimized by Q10 treatment.”
Coenzyme Q10 Cardioprotective Effects Against Doxorubicin-Induced Cardiotoxicity in Wistar Rat“However, Q10 effectively protected cardiomyocytes and ameliorated fibrosis and cell death induced by doxorubicin.”
“Concomitant administration of CoQ10 with DOX significantly restored testicular oxidative stress parameters and the distorted histopathological picture, reduced the up-regulation of caspase 3 caused by DOX, and increased P-gp expression.”
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