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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Ubiquinone
drug:
Atovaquone
Research Papers that Mention the Interaction
“Several major anti-parasitic drugs, such as atovaquone and endochin-like quinolones, act through inhibition of the mitochondrial electron transport chain at the coenzyme Q :cytochrome c oxidoreductase complex (Complex III).”
Divergent features of the coenzyme Q:cytochrome c oxidoreductase complex in Toxoplasma gondii parasites.“The discovery that atovaquone also inhibits biosynthesis of ubiquinone in P. carinii may unfold other mechanisms by which drug resistance develops.”
“Thus, atovaquone has inhibitory activity on both electron transport and CoQ synthesis in this pathogen.”
Ubiquinone Synthesis in Mitochondrial and Microsomal Subcellular Fractions of Pneumocystis spp.: Differential Sensitivities to Atovaquone“Our group previously demonstrated that atovaquone, but not stigmatellin (CoQ analog that is not a naphthoquinone), has additional activity in P. carinii [2]; atovaquone inhibited the synthesis of all four CoQ homologs.”
“However, we observed that when intact organisms were treated with only 10 nM atovaquone , the biosynthesis of CoQ was also dramatically inhibited, and a complex triphasic response occurred as drug concentration was increased [3].”
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