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Last Updated: a year ago

Possible Interaction: Ubiquinone and Atovaquone



Research Papers that Mention the Interaction

Several major anti-parasitic drugs, such as atovaquone and endochin-like quinolones, act through inhibition of the mitochondrial electron transport chain at the coenzyme Q :cytochrome c oxidoreductase complex (Complex III).
PLoS pathogens  •  2021  |  View Paper
The discovery that atovaquone also inhibits biosynthesis of ubiquinone in P. carinii may unfold other mechanisms by which drug resistance develops.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy  •  2001  |  View Paper
Thus, atovaquone has inhibitory activity on both electron transport and CoQ synthesis in this pathogen.
Eukaryotic Cell  •  2005  |  View Paper
Our group previously demonstrated that atovaquone, but not stigmatellin (CoQ analog that is not a naphthoquinone), has additional activity in P. carinii [2]; atovaquone inhibited the synthesis of all four CoQ homologs.
The Journal of eukaryotic microbiology  •  2003  |  View Paper
However, we observed that when intact organisms were treated with only 10 nM atovaquone , the biosynthesis of CoQ was also dramatically inhibited, and a complex triphasic response occurred as drug concentration was increased [3].
The Journal of eukaryotic microbiology  •  2001  |  View Paper