Possible Interaction: Ubiquinone and Atorvastatin

“ Atorvastatin administration resulted in a significant decrease in blood levels of total cholesterol, triglycerides, low-density lipoprotein (LDL) cholesterol, vitamin E, and CoQ10 (P < .05); however, a significant increase in the ratios of vitamin E/LDL cholesterol and CoQ10/LDL cholesterol was noted (P < .05).”

“… CoQ10 plasma … atorvastatin in the complex therapy is statistically significantly lower (−15.2 Δ%), and in patients taking amlodipine or ethoxidol is statistically significantly higher (+18.….2 Δ%, respectively) than in patients of control groups (a group of patients who receive the same drugs, except for the studied one).”

“Under these conditions, plasma levels of CoQ10 were reduced by atorvastatin (−26.1%, P=0.0007) but not by pitavastatin (−7.7%, P=0.39), although no adverse events or abnormalities of liver and muscle enzyme were observed after either statin treatment.”

“In conclusion atorvastatin definitely decreased plasma CoQ10 levels and supplementation with CoQ10 increased their levels.”

“Rundek T, Naini A, Sacco R et al. Atorvastatin decreases the coenzyme Q10 level in the blood of patients at risk for cardiovascular disease and stroke.”

“Simvastatin and atorvastatin were more potent in inducing dose‐dependent INS1E cell death (10–15‐fold), which were also attenuated by CoQ 10 cotreatment.”

“These results were augmented when atorvastatin was combined with CoQ10 and/or Vit.”

“Additionally, atorvastatin can interfere with mitochondrial function by reducing the level of Q10.”

“Furthermore, only combination of ATV and Q10 decreased the 6-OHDA induced expression of cytochrome-C, caspase-9 and caspase-3.”

“Therefore, current results provide evidence that supplementation of Q10 with ATV shows synergistic effect in reducing dopamine toxicity.”

“ConclusionsCoadministration of l-carnitine, but not coenzyme Q10 , enhances the anti-osteoporotic effect of atorvastatin while antagonizing myopathy in ovariectomized rats.”

“This study was designed to assess which agent, l-carnitine or coenzyme Q10 , could enhance the anti-osteoporotic effect of atorvastatin while antagonizing myopathy in ovariectomized rats.”

“A high dose of atorvastatin (20 mg/kg/day) was significantly reduced the myocardium content of coenzyme Q10 as compared with isoproterenol treated group (p<0.001).”

“Compared with atorvastatin alone treated animals, co-administration of coenzyme Q10 with atorvastatin was improved the level of coenzyme Q10 in the myocardium (p<0.05, p<0.001).”