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Last Updated: a year ago

Possible Interaction: Ubiquinone and Atorvastatin



Research Papers that Mention the Interaction

Atorvastatin administration resulted in a significant decrease in blood levels of total cholesterol, triglycerides, low-density lipoprotein (LDL) cholesterol, vitamin E, and CoQ10 (P < .05); however, a significant increase in the ratios of vitamin E/LDL cholesterol and CoQ10/LDL cholesterol was noted (P < .05).
Nutrition research  •  2010  |  View Paper
CoQ10 plasma … atorvastatin in the complex therapy is statistically significantly lower (−15.2 Δ%), and in patients taking amlodipine or ethoxidol is statistically significantly higher (+18.….2 Δ%, respectively) than in patients of control groups (a group of patients who receive the same drugs, except for the studied one).
Drug metabolism and personalized therapy  •  2020  |  View Paper
Under these conditions, plasma levels of CoQ10 were reduced by atorvastatin (−26.1%, P=0.0007) but not by pitavastatin (−7.7%, P=0.39), although no adverse events or abnormalities of liver and muscle enzyme were observed after either statin treatment.
Clinical pharmacology and therapeutics  •  2008  |  View Paper
In conclusion atorvastatin definitely decreased plasma CoQ10 levels and supplementation with CoQ10 increased their levels.
Atherosclerosis  •  2007  |  View Paper
Rundek T, Naini A, Sacco R et al. Atorvastatin decreases the coenzyme Q10 level in the blood of patients at risk for cardiovascular disease and stroke.
Journal of the American Geriatrics Society  •  2006  |  View Paper
Simvastatin and atorvastatin were more potent in inducing dose‐dependent INS1E cell death (10–15‐fold), which were also attenuated by CoQ 10 cotreatment.
Journal of cellular physiology  •  2019  |  View Paper
These results were augmented when atorvastatin was combined with CoQ10 and/or Vit.
Life sciences  •  2018  |  View Paper
Additionally, atorvastatin can interfere with mitochondrial function by reducing the level of Q10.
Furthermore, only combination of ATV and Q10 decreased the 6-OHDA induced expression of cytochrome-C, caspase-9 and caspase-3.
Therefore, current results provide evidence that supplementation of Q10 with ATV shows synergistic effect in reducing dopamine toxicity.
Neurotoxicity Research  •  2016  |  View Paper
ConclusionsCoadministration of l-carnitine, but not coenzyme Q10 , enhances the anti-osteoporotic effect of atorvastatin while antagonizing myopathy in ovariectomized rats.
This study was designed to assess which agent, l-carnitine or coenzyme Q10 , could enhance the anti-osteoporotic effect of atorvastatin while antagonizing myopathy in ovariectomized rats.
Journal of Zhejiang University-SCIENCE B  •  2016  |  View Paper
A high dose of atorvastatin (20 mg/kg/day) was significantly reduced the myocardium content of coenzyme Q10 as compared with isoproterenol treated group (p<0.001).
Compared with atorvastatin alone treated animals, co-administration of coenzyme Q10 with atorvastatin was improved the level of coenzyme Q10 in the myocardium (p<0.05, p<0.001).
Drug research  •  2014  |  View Paper
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