supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
drug:
Ubenimex
supplement:
Resveratrol
Research Papers that Mention the Interaction
“Notably, resveratrol exerted relatively stronger inhibitory effects than bestatin , an established inhibitor of LTA(4)H activity, and the inhibitory effects of resveratrol were reduced in cells where LTA(4)H was suppressed by shRNA-mediated knockdown.”
Resveratrol, a red wine polyphenol, suppresses pancreatic cancer by inhibiting leukotriene A₄hydrolase.“In this study, we found that resveratrol enhanced the anti‐proliferative activity of bestatin in K562/ADR cells.”
“ Resveratrol increased the intracellular concentration of bestatin through inhibiting P‐gp function and downregulating P‐gp expression at mRNA and protein levels, which increased anti‐proliferative activity of bestatin in K562/ADR cells.”
“These results demonstrated that resveratrol could increase the anti‐proliferative activity of bestatin through downregulating P‐gp expression via suppressing the PI3K/Akt/mTOR signaling pathway.”
“Peripheral antinociception of RES intermediate‐dose (50 &mgr;g/paw) was increased by: (i) bestatin , inhibitor of endogenous opioid degradation involved‐enzymes; (ii) MAFP, inhibitor of anandamide amidase; (iii) JZL184, inhibitor of 2‐arachidonoylglycerol degradation involved‐enzyme; (iv) VDM11, endocannabinoid reuptake inhibitor.”
Evidence for the involvement of opioid and cannabinoid systems in the peripheral antinociception mediated by resveratrol
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback