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Last Updated: 3 months ago

Possible Interaction: Ubenimex and Resveratrol



Research Papers that Mention the Interaction

Notably, resveratrol exerted relatively stronger inhibitory effects than bestatin , an established inhibitor of LTA(4)H activity, and the inhibitory effects of resveratrol were reduced in cells where LTA(4)H was suppressed by shRNA-mediated knockdown.
Cancer research  •  2010  |  View Paper
In this study, we found that resveratrol enhanced the anti‐proliferative activity of bestatin in K562/ADR cells.
Resveratrol increased the intracellular concentration of bestatin through inhibiting P‐gp function and downregulating P‐gp expression at mRNA and protein levels, which increased anti‐proliferative activity of bestatin in K562/ADR cells.
These results demonstrated that resveratrol could increase the anti‐proliferative activity of bestatin through downregulating P‐gp expression via suppressing the PI3K/Akt/mTOR signaling pathway.
Journal of cellular biochemistry  •  2016  |  View Paper
Peripheral antinociception of RES intermediate‐dose (50 &mgr;g/paw) was increased by: (i) bestatin , inhibitor of endogenous opioid degradation involved‐enzymes; (ii) MAFP, inhibitor of anandamide amidase; (iii) JZL184, inhibitor of 2‐arachidonoylglycerol degradation involved‐enzyme; (iv) VDM11, endocannabinoid reuptake inhibitor.
Toxicology and applied pharmacology  •  2019  |  View Paper