Possible Interaction: Tyrosine and Vitamin C

“High doses of ascorbic acid were shown to arrest or significantly inhibit the excretion of carcinogenic metabolite of tyrosine in patients with hemoblastoses and nephroblastoma.”

“3) Hydroxylation of tyrosine in the presence of ascorbic acid.”

“Administration of vitamin C reduced the increased values of tyrosine in thyrotoxicosis to normal levels.”

“It has been known for a number of years that vitamin C is necessary for the normal metabolism of tyrosine.”

“This oxidation of deoxyguanosine, as well as the peroxynitrite-mediated nitration of tyrosine to 3-nitrotyrosine, was significantly inhibited by ascorbic acid , glutathione and (−)-epigallocatechin gallate, a polyphenolic antioxidant present in tea.”

“ Ascorbic acid pretreatment afforded a marked protection against tyrosine toxicity.”

“ Ascorbic acid can alleviate, though not completely counteract, the adverse effect of excess dietary tyrosine.”

“The native fluorescence intensity of tyrosine was quenched using ascorbic acid.”

“When tyrosine was oxidized in the presence of ascorbic acid , 5-OH-dopa formation represented 14% of the original amount of tyrosine.”

“The content of vitamin C in the guinea-pig liver rapidly decreases by the administration of tyrosine , cystine and histidine, but is little influenced by alanine, glutamic acid and arginine.8.”