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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Tyrosine
drug:
Valproic Acid
Research Papers that Mention the Interaction
“Glutamine, methionine, tyrosine , and phenylalanine CSF/plasma ratios were elevated with valproate therapy.”
CSF/plasma ratios of amino acids: Reference data and transports in children“Cerebrospinal fluid/plasma ratios of glutamine and tyrosine were significantly elevated by valproate therapy and those of serine, asparagine, glutamine, valine, methionine, and phenylalanine by phenobarbital therapy.”
“ VPA increased NO production in BAECs, which was accompanied by a decrease in phosphorylation of eNOS at serine 116 (eNOS-Ser(116)) and cyclin-dependent kinase 5 at tyrosine 15 (CDK5-Tyr(15)).”
Valproic acid increases NO production via the SH-PTP1-CDK5-eNOS-Ser(116) signaling cascade in endothelial cells and mice.
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