Possible Interaction: Tyrosine and Trastuzumab

“An anti-ERBB2 mono clonal antibody 4D5, which was later humanized to generate trastuzumab, was … inhibitory effect on ERBB2overexpressing breast cancer cells.6 Growing evidence indicates that targeting ERBB2 using trastuzumab … tyrosine phosphorylation in trastuzumab-sensitive breast cancer cells.7–…-sensitive breast Trastuzumab is not a tyrosine kinase inhibitor”

“Treatment of BT-474 cells with Herceptin inhibited the constitutive tyrosine phosphorylation of HER3 and disrupted the basal association of HER3 with HER2 and of HER3 with p85alpha potentially explaining the inhibition of PI3K.”