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Discover Supplement-Drug Interactions

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Last Updated: 4 years ago

Possible Interaction: Tyrosine and Sorafenib

supplement:

Tyrosine

Research Papers that Mention the Interaction

Sorafenib is a small molecular inhibitor of intracellular tyrosine and serine/threonine protein kinases (VEGFR, PDGFR, CRAF and BRAF), and is thought also to induce autophagy, a chief mechanism influencing tumor growth.
Current drug targets  •  2016  |  View Paper
Sorafenib is an inhibitor of multi-kinases including tyrosine and serine/threonine kinases.
Pulmonary pharmacology & therapeutics  •  2017  |  View Paper
Sorafenib … tyrosine and serine/threonine kinases (vascular endothelial growth factor (VEGF) receptor 2 and 3, platelet derived growth factor (PDGF) receptor B-Raf, Raf-1, Flt3, … include diarrhea, hypertension, fatigue, and cutaneous lesions (facial and scalp erythema, focal acral erythema/acral erythrodysesthesia/hand-foot syndrome, alopecia, and splinter hemorrhages).
Journal of the American Academy of Dermatology  •  2007  |  View Paper
Up to 8-fold SFB dose-dependent (5-15 μM) decrease in phosphorylation of RIN1 at tyrosine 36 , but not in total RIN1 expression, was observed.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology  •  2009  |  View Paper