“ Sorafenib … tyrosine and serine/threonine kinases (vascular endothelial growth factor (VEGF) receptor 2 and 3, platelet derived growth factor (PDGF) receptor B-Raf, Raf-1, Flt3, … include diarrhea, hypertension, fatigue, and cutaneous lesions (facial and scalp erythema, focal acral erythema/acral erythrodysesthesia/hand-foot syndrome, alopecia, and splinter hemorrhages).”