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Last Updated: 3 years ago

Possible Interaction: Tyrosine and Recombinant Interferon Beta

supplement:

Tyrosine

drug:

Recombinant Interferon Beta

Research Papers that Mention the Interaction

“Most importantly, in UBP43-deficient cells, IFN-beta induces a prolonged Stat1 tyrosine phosphorylation, DNA binding, and IFN-mediated gene activation.”
Protein ISGylation modulates the JAK-STAT signaling pathway.
Genes & development  •  2003  |  View Paper
“In contrast, tyrosine phosphorylation of both STAT1 and STAT2 was inhibited in these cells after IFN-beta stimulation.”
Measles virus V protein blocks interferon (IFN)-alpha/beta but not IFN-gamma signaling by inhibiting STAT1 and STAT2 phosphorylation.
FEBS letters  •  2003  |  View Paper
“Secondly, in untreated patients with stable MS, culture with IFN-beta induced excessive tyrosine phosphorylation of STAT1, and this correlated with low SHP1 tyrosine phosphatase levels.”
Low expression of interferon-stimulated genes in active multiple sclerosis is linked to subnormal phosphorylation of STAT1
Journal of Neuroimmunology  •  2002  |  View Paper
“We found that IFN-beta induced phosphorylation on tyrosine of STAT3 in U1.wt cells but not in U1.KR930 cells, whereas STAT1 and STAT2 were activated in both cell lines.”
Catalytically active TYK2 is essential for interferon-beta-mediated phosphorylation of STAT3 and interferon-alpha receptor-1 (IFNAR-1) but not for activation of phosphoinositol 3-kinase.
The Journal of biological chemistry  •  1999  |  View Paper
“Prior treatment of U266 cells with IFN-beta downregulated IL-6-induced tyrosine phosphorylation of gp130, Jak2, PTP1D/Syp, Shc, and Erk2, and GTP-loading of p21ras.”
Interferon-beta interrupts interleukin-6-dependent signaling events in myeloma cells.
Blood  •  1997  |  View Paper
“Treatment of cells with IFN-beta induced tyrosine phosphorylation and activation of MAPK and caused MAPK and Stat1 alpha to coimmunoprecipitate.”
Requirement for MAP kinase (ERK2) activity in interferon alpha- and interferon beta-stimulated gene expression through STAT proteins.
Science  •  1995  |  View Paper
“ IFN-beta and IFN-gamma induced a strong increase of STAT1 and STAT3 tyrosine phosphorylation, while the effect of IFN-alpha was much weaker.”
Inhibitory effects of interferons on pancreatic stellate cell activation.
World journal of gastroenterology  •  2006  |  View Paper
“Low, but not high doses of IFN-beta caused enhanced tyrosine phosphorylation of STAT1 and STAT4, suppressed the levels of suppressor of cytokine signaling-1, and up-regulated the expression of inducible NO synthase in vivo.”
Protection against progressive leishmaniasis by IFN-beta.
Journal of immunology  •  2004  |  View Paper
“ IFN-beta-mediated suppression is partially or completely prevented by catalase, 2-mercaptoethanol, and certain peroxidase substrates (ascorbic acid, potassium iodide, and tyrosine).”
Activation of a suppressor T-cell pathway by interferon.
Proceedings of the National Academy of Sciences of the United States of America  •  1982  |  View Paper