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Last Updated: 3 years ago

Possible Interaction: Tyrosine and Nitisinone



Research Papers that Mention the Interaction

FAH−/− rabbits exhibit phenotypic features of HT1 including liver and kidney abnormalities but additionally develop frequent ocular manifestations likely caused by local accumulation of tyrosine upon NTBC administration.
The Journal of Biological Chemistry  •  2017  |  View Paper
The high tyrosine concentrations caused by treatment with NTBC could result in ophthalmological and skin problems and requires life-long dietary restriction of tyrosine and its precursor phenylalanine, which could be strenuous to adhere to.
Pediatric Drugs  •  2019  |  View Paper
Nitisinone inhibits the degradation of tyrosine and thereby the production of harmful metabolites, however, the concentration of tyrosine also increases.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics  •  2019  |  View Paper
Serum tyrosine and urinary 3-MT increased significantly following treatment with nitisinone.
Serum tyrosine increased at least 6-fold following nitisinone (p ≤ 0.0001, all visits), and urinary 3-methoxytyramine (3-MT) increased at 12 and 24 months (p ≤ 0.0001), and 5-hydroxyindole acetic acid (5-HIAA) decreased at 12 months (p = 0.03).
Molecular genetics and metabolism  •  2018  |  View Paper
Nitisinone produced an increase in tyrosine and catecholamine metabolite (HVA, VMA, and metanephrines) levels.
Pediatric blood & cancer  •  2006  |  View Paper
Plasma tyrosine and homogentisic acid increased (9-fold, p = < 0.0001) and decreased (9-fold, p = 0.004), respectively in HGD−/− mice treated with nitisinone.
Tyrosine (10-fold in both comparisons, p = 0.003; [BALB/c HGD−/− (n = 6) and BALB/c HGD+/− (n = 6) (no treatment) vs. BALB/c HGD−/− (n = 6, treated)] and tyramine (25-fold, p = 0.02; 32-fold, p = 0.02) increased significantly following treatment with nitisinone.
Metabolomics  •  2019  |  View Paper
In laboratory animals, treatment with nitisinone leads to the elevation of plasma tyrosine (tyrosinaemia).
Mathematical medicine and biology : a journal of the IMA  •  2017  |  View Paper
Nitisinone effectively blocks the metabolism of tyrosine to prevent the formation of the toxic compound succinylacetone (and precursor fumarylacetoacetate) in affected children.
JIMD reports  •  2019  |  View Paper
Urinary excretion of HGA decreases in a concentration-dependent manner, while the increase in tyrosine is less clearly related to nitisinone concentrations.
JIMD reports  •  2015  |  View Paper