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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Tyrosine
Research Papers that Mention the Interaction
“It has been suggested that MDMA depletes 5-HT by increasing brain tyrosine levels, which via non-enzymatic hydroxylation leads to DA-derived free radical formation.”
On the role of tyrosine and peripheral metabolism in 3,4-methylenedioxymethamphetamine-induced serotonin neurotoxicity in rats“Overall, the findings suggest that MDMA depletes 5-HT by increasing tyrosine and its eventual conversion to DA within 5-HT terminals.”
“The local infusion of l-tyrosine into the striatum or hippocampus during MDMA administration potentiated the acute increase in extracellular DA and the long-term depletion of 5-HT after MDMA.”
“These results show that MDMA increases the concentration of tyrosine in the brain to cause a long-term depletion of 5-HT via the nonenzymatic, tyrosine hydroxylase-independent, hydroxylation of tyrosine to DOPA and subsequently to DA via AADC.”
“The repeated administration of MDMA produced a sustained increase in the extracellular concentration of 2,3‐DHBA and p‐tyrosine , as well as dopamine.”
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