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Last Updated: 2 years ago

Possible Interaction: Tyrosine and Interleukin-10

supplement:

Tyrosine

Research Papers that Mention the Interaction

Stat3 tyrosine phosphorylation can be induced in RH/K30 by treatment with IL-10.
Immunology letters  •  2007  |  View Paper
IL-10 initiates anergy in T cells by blocking tyrosine phosphorylation of CD28 and inhibiting the CD28 co-stimulatory signal.
Current opinion in allergy and clinical immunology  •  2001  |  View Paper
IL‐10 inhibited tyrosine phosphorylation of CD28; thus, the phosphatidylinositol 3‐kinase binding to CD28 was blocked.
European journal of immunology  •  2000  |  View Paper
IL‐10 inhibits CD28 tyrosine phosphorylation, preventing the binding of phosphatidylinositol 3‐kinase p85 and consequently inhibiting the CD28 signalling pathway.
Immunology  •  2006  |  View Paper
Immunoblot assays of activating transcription factor (ATF) 3 immunoprecipitates with tyrosine specific antibodies revealed that IL-10 stimulated tyrosine phosphorylation of ATF3 to activate binding to the CREB domain and suppress MMP-2 expression.
Molecular cancer research : MCR  •  2004  |  View Paper
Signalling cascade studies revealed that IL-10 stimulated tyrosine phosphorylation of JAK1 and TYK2 receptor kinases and tyrosine phosphorylation of IL-10E1.
British Journal of Cancer  •  2003  |  View Paper
In addition, IL-10 induced tyrosine (Tyr) phosphorylation of Erk, as well as serine (Ser) and Tyr phosphorylation of STAT-3.
Biological & pharmaceutical bulletin  •  2003  |  View Paper
IL-10 did not change the expression of mRNA of both GM-CSFR α-chain and β-chain, but inhibited tyrosine phosphorylation of STAT5 and extracellular signal-regulated kinases 1 and 2 in the monocytes.
The Journal of Immunology  •  2001  |  View Paper
Accordingly, IL-10 binding to its receptor inhibits CD28 tyrosine phosphorylation, the initial step of the CD28 signaling pathway.
International Archives of Allergy and Immunology  •  2001  |  View Paper
IL‐10 inhibits CD28 tyrosine phosphorylation, the initial step of the CD28 signalling pathway, and consequently the phosphatidylinositol 3‐kinase p85 binding to CD28.
Immunology  •  2001  |  View Paper
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