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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Tyrosine
drug:
Hypochlorite
Research Papers that Mention the Interaction
“Cl-Tyr and diCl-Tyr were also formed from free tyrosine but then reacted further with HOCl.”
“In this study, we aimed to investigate the formation of Cl-Tyr from reaction of HOCl with tyrosine (both free and peptide-bound) and the fate of Cl-Tyr under such conditions.”
Reactions of Hypochlorous Acid with Tyrosine and Peptidyl-tyrosyl Residues Give Dichlorinated and Aldehydic Products in Addition to 3-Chlorotyrosine*“At the same time, free tyrosine can influence MPO-induced protein oxidation due to its ability to modulate HOCl synthesis in the MPO active site.”
“At pH 7.4 we detected an increased HOCl production in the presence of tyrosine not only by the MPO-H(2)O(2)-Cl(-) system but also in suspensions of zymosan-activated neutrophils.”
“The reaction of protein with HOCl resulted in changes in protein conformation as assessed by the UV fluorescence and oxidation of the unique methionine and tyrosine , chlorination of several lysines with formation of chloramines.”
Oxidation of Cu,Zn-superoxide Dismutase by the Myeloperoxidase/Hydrogen Peroxide/Chloride System: Functional and Structural Effects“Amino acid analysis indicated that tyrosine was also degraded by hypochlorite , but we could not detect a carbonyl group formed at tyrosine.”
“Cysteine, tryptophan, and methionine were proven to be the most vulnerable amino acids for degradation upon hypochlorous and peracetic acid treatment, while tyrosine was only prone to degradation in the presence of hypochlorous acid.”
Hypochlorous and peracetic acid induced oxidation of dairy proteins.
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