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Last Updated: 4 years ago

Possible Interaction: Tyrosine and Gw572016

supplement:

Tyrosine

Research Papers that Mention the Interaction

Tyrosine phosphorylation of HER2 and HER3, AR transactivation, and cell proliferation induced by heregulin were more potently inhibited by the EGFR/HER2 dual tyrosine kinase inhibitor GW572016 (lapatinib) than the EGFR-specific inhibitor ZD1839 (gefitinib).
Clinical Cancer Research  •  2005  |  View Paper
GW572016 markedly reduced tyrosine phosphorylation of EGFR and erbB2, and inhibited activation of Erk1/2 and AKT, downstream effectors of proliferation and cell survival, respectively.
Oncogene  •  2002  |  View Paper