Possible Interaction: Tyrosine and Glutamic Acid

“Substitution of glutamic acid 130 with tyrosine resulted in dramatically increased nucleotidase activities, while mutagenesis of aspartic acid 151 to alanine and aspartic acid 84 to alanine completely abolished activity.”

“Only the copolymer of l-glutamic acid and l-tyrosine [poly(Glul1.16, Tyrl)] (Mr= 22600) exerts a relevant non-com- petitive inhibition, while none of the tested synthetic polypeptides is active as substrate.”

“ Tyrosine exerted a significant stimulating effect on the absorption of most amino acids absorbed from the caecum, e.g. Asp-NH2, Ser, Thr, Arg, Asp, Glu.”

“Plasma free amino acid concentrations were considerably decreased and total indispensable amino acid concentration (including cystine and tyrosine ) was reduced to approximately a half or less with L-glutamic acid supplementation.”

“Supplementation of levels of L-glutamic acid to an amino acid mixture containing adequate levels of all the indispensable amino acids plus cystine and tyrosine resulted in increased growth up to 10% L-glutamic acid in the diet.”

“The addition of glutamic acid decreased the plasma concentration of threonine, serine, tyrosine , and phenylalanine.”

“The experiments described below indicate that the copolymer of tyrosine and glutamic acid studied is a much more efficient inhibitor of RNase than polyaspartic acid, and that in this case the attachment to the enzyme occurs not only through electrostatic interactions but also through short range urea-labile bonds.”

“Although the attachment of polar amino acid residues alone does not significantly enhance the antigenicity of gelatin (Sela & Arnon, 1960), glutamic acid in company with tyrosine affected both the extent and the specificity of the immunological response.”