Possible Interaction: Tyrosine and Colforsin

“The anti-proliferative effect of high levels of tyrosine was not restricted to alpha-MSH; tyrosine also reduced proliferation induced by forskolin , a direct activator of the cAMP pathway.”

“Immunoprecipitations followed by anti-phosphotyrosine immunoblots indicate that tyrosine phosphorylation of the α chain of the IFNα/β receptor, Jak1, Tyk2, as well as Stat1 and Stat2 is reduced as a consequence of incubation of cells with forskolin.”

“Furthermore, phorbol ester and forskolin treatment of cells before CD3 stimulation reduces the level of tyrosine phosphorylation of PLC gamma 1 and the PLC activity associated with APTyr Ab.”

“In addition, forskolin treatment induced tyrosine phosphorylation of epidermal growth factor receptor.”

“Both Bt(2)cAMP, a permeable analogue of cAMP, and forskolin , which directly activates adenylate cyclase, also induced an increase in Tyr phosphorylation of p38 MAP kinase.”

“Furthermore, forskolin increased tyrosine phosphorylation of approximately 70- to 80-, approximately 97-, and approximately 110- to 120-kDa proteins.”

“Finally, forskolin (10‐‐5M) produced a 40% increase in the rate of [3H]dopamine synthesis from [3H]tyrosine.”

“ Forskolin stimulates the conversion of tyrosine to dopamine in slices and synaptosomes from rat striatum, in synaptosomes from rat hypothalamus, and in slices from bovine retina.”

“Furthermore, forskolin increased tyrosine phosphorylation of ∼70- to 80-, ∼97-, and ∼110- to 120-kDa proteins.”