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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Tyrosine
drug:
Aldesleukin
Research Papers that Mention the Interaction
“Activation by IL-2 led to rapid tyrosine phosphorylation and redistribution of Jak3.”
Janus Kinase 3 Regulates Interleukin 2-induced Mucosal Wound Repair through Tyrosine Phosphorylation of Villin*“ Costimulation with SCF was found to increase and prolong tyrosine phosphorylation of JAK2 and the TPO receptor c‐mpl.”
“Stimulation with IL-2 induces the tyrosine phosphorylation and activation of the Janus kinases Jak1 and Jak3.”
“Furthermore, tyrosine phosphorylation of the cellular proteins (p120, p98, p96, p54, and p38) was induced or enhanced in response to the addition of IL-2 in ED515-D and Kit225 cells, but not in the cell lines expressing pseudo- high affinity IL-2R.”
“By the use of immunoblotting with anti-phosphotyrosine antibodies, we demonstrate that IL-2 augments tyrosine phosphorylation of the IL-2 receptor beta chain in human cell lines expressing either high-affinity (alpha/beta) receptors or only the beta chain.”
“ Interleukin-2 (IL-2) stimulates the rapid phosphorylation on tyrosine of several specific cellular proteins.”
“This led to impaired STAT tyrosine phosphorylation in response to IL-2 and IL-21, reduced expression of IL-2 target genes in patient CD4+ T cells, and reduced cell proliferation in response to IL-2 stimulation.”
“ IL-2 challenge enhanced tyrosine phosphorylation of Janus-activated kinase (JAK)1–3 and STAT5, and induced JAK1 and JAK2 to associate with STAT5 in IL-2–dependent ATL cells.”
“CD3 and CD28 costimulation induced a complex response including decreased threonine phosphorylation in the ERK1 and ERK2 activation loops and increased phosphorylation of selected tyrosine sites on ERK1/2, p38, phospholipase C-γ, Src homology 2 domain-containing transforming protein 1, Grap2, and Vav-1, potentiating T cell activation.”
“In INA‐6.Tu11 cells, a subline of the IL‐6‐dependent human plasma cell line INA‐6 expressing gp130 and the receptor for leukaemia inhibitory factor (LIF), stimulation with BSF‐3 induced tyrosine phosphorylation of signal transducer and activator of transcription 3 (STAT3).”
“Increased tyrosine phosphorylation was observed in FLS lysates following 30-min incubation with IL-2.”
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