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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Tyrosine
supplement:
3-Nitrotyrosine
Research Papers that Mention the Interaction
“Using gas chromatography-mass spectrometry … 10-fold increase in 3-nitrotyrosine (NO2Y) content, a global marker of protein modification by reactive nitrogen species, … recovered from bronchoalveolar lavage of severe asthmatic patients (480 ± 198 μmol/mol tyrosine ; n = 11) compared with nonasthmatic subjects (52.….7 μmol/mol tyrosine; n = 12).”
Eosinophils Are a Major Source of Nitric Oxide-Derived Oxidants in Severe Asthma: Characterization of Pathways Available to Eosinophils for Generating Reactive Nitrogen Species4“ 3-NT increased 3.5-fold in tubules exposed to ANG II (10(-7) M) (0.0054 +/- 0.0019 3-NT/100 tyrosines for control and 0.019 +/- 0.0058 3-NT/100 tyrosines for ANG II, P < .05; n = 4) and L-NMMA prevented the increase.”
Peroxynitrite and the regulation of Na(+),K(+)-ATPase activity by angiotensin II in the rat proximal tubule.“However, in competition with tyrosine 20-fold higher concentrations of nitrotyrosine were necessary before its incorporation became evident.”
“Incorporation of tyrosine into tubulin was competitively inhibited by nitrotyrosine with an apparent K(i) of 0.24 mM. The TTL-catalysed incorporation of nitrotyrosine as sole substrate into alpha-tubulin was clearly detectable at concentrations of 10 microM by immunological methods using nitrotyrosine specific antibodies.”
“Very high concentrations of l-3-nitrotyrosine were required to inhibit l-tyrosine tRNA formation in vitro .”
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