Possible Interaction: Tyramine and Yohimbine

“The inhibitory effect of TA at 10 µM is eliminated by coincubation with yohimbine , phentolamine or chlorpromazine (each 10 µM).”

“The inhibitory effect of tyramine is abolished by co-incubation with either yohimbine or chlorpromazine.”

“The inhibitory effect of TA at 1 µm was abolished by yohimbine and chlorpromazine (each 10 µm).”

“ Tyramine containing foods (red wine, liver, cheese) and nasal decongestants or diet aids containing phenylpropanolamine should be strictly avoided when yohimbine is used, to prevent a hypertensive crisis.”

“ Tyramine induced a dose-dependent decrease in FBF (p less than 0.001) which was reduced by yohimbine (p less than 0.01), as well as by doxazosin (p less than 0.01), and abolished by the combination of both alpha-adrenoceptor antagonists (p less than 0.001).”

“Both these vasoconstrictions were significantly reduced by yohimbine (P < 0.001 for both) as well as by doxazosin (P < 0.05 for noradrenaline and P < 0.001 for tyramine).”

“Phentolamine, prazosin or a combination of prazosin and yohimbine caused an inhibition of the hypertensive effect of tyramine , but propranolol, atenolol and/or atropine had no effect.”

“The adrenergic blocking agents yohimbine and dibenamine, though ineffective on their own, antagonized the action of amphetamine and tyramine.”

“The antiamnestic effect of tyramine and adrenaline is antagonized by the simultaneous administration of prazosin or yohimbine , but not by that of propranolol.”

“The contractile responses to norepinephrine and tyramine were inhibited to a greater extent by yohimbine than by prazosin in both saphenous and femoral veins, suggesting that norepinephrine released from perivascular nerve terminals activates preferentially postsynaptic alpha 2-adrenoceptors.”