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Last Updated: 6 months ago

Possible Interaction: Tubocurarine and Vecuronium

supplement:

Tubocurarine

Research Papers that Mention the Interaction

Despite the higher TOF ratio, the priming dose of VEC accelerated the onset time of intubation dose of TC more than the priming dose of TC (P = 0.0018).
European Journal of Clinical Pharmacology  •  1999  |  View Paper
However, pancuronium and vecuronium each shifted the apparent IC50 of (+)-tubocurarine less than expected for complete competition but more than expected for independent binding.
Molecular Pharmacology  •  2009  |  View Paper
The results showed the combination of vecuronium plus d-tubocurarine to be significantly more potent (P < 0.05) than would be expected from a simple additive effect of the individual drugs given alone.
To evaluate possible potentiation of neuromuscular blocking effect of a combination of vecuronium and d-tubocurarine , cumulative dose-response curves were constructed to compare the potency of this combination with vecuronium arid d-tubocurarine given alone.
Anesthesia and analgesia  •  1985  |  View Paper
Vecuronium caused a significantly smaller response than both atracurium and d‐tubocurarine.
Acta anaesthesiologica Scandinavica  •  1983  |  View Paper
Increases in [Ca2+]1 caused by both pancuronium and vecuronium were prevented by the non-subtype-specific nicotinic acetylcholine receptor antagonist D-tubo-curarine and were reduced 44–73% by atropine.
Anesthesiology  •  1994  |  View Paper
The effect of d-tubocurarine was also potentiated by vecuronium , pancuronium and pipecuronium.
Journal of Anesthesia  •  2010  |  View Paper