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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Tubocurarine
drug:
Vecuronium
Research Papers that Mention the Interaction
“Despite the higher TOF ratio, the priming dose of VEC accelerated the onset time of intubation dose of TC more than the priming dose of TC (P = 0.0018).”
Neuromuscular blocking characteristics of vecuronium after tubocurarine-induced “fade”An experimental double-blind clinical study“However, pancuronium and vecuronium each shifted the apparent IC50 of (+)-tubocurarine less than expected for complete competition but more than expected for independent binding.”
“The results showed the combination of vecuronium plus d-tubocurarine to be significantly more potent (P < 0.05) than would be expected from a simple additive effect of the individual drugs given alone.”
“To evaluate possible potentiation of neuromuscular blocking effect of a combination of vecuronium and d-tubocurarine , cumulative dose-response curves were constructed to compare the potency of this combination with vecuronium arid d-tubocurarine given alone.”
“ Vecuronium caused a significantly smaller response than both atracurium and d‐tubocurarine.”
“Increases in [Ca2+]1 caused by both pancuronium and vecuronium were prevented by the non-subtype-specific nicotinic acetylcholine receptor antagonist D-tubo-curarine and were reduced 44–73% by atropine.”
Activation of Brain Acetylcholine Receptors by Neuromuscular Blocking Drugs: A Possible Mechanism of Neurotoxicity“The effect of d-tubocurarine was also potentiated by vecuronium , pancuronium and pipecuronium.”
Interactions between ORG9426 and other non-depolarizing neuromuscular blocking agents in ratsin vivo
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