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Last Updated: 3 months ago

Possible Interaction: Tubocurarine and Hexamethonium

Research Papers that Mention the Interaction

The positive inotropic effects of all three drugs are blocked by ganghionic blocking agents hexamethonium , tetracthmylammonium and d tubocurarine).
The Journal of pharmacology and experimental therapeutics  •  1959  |  View Paper
High DMPP concentrations (10 and 30 μM) enhanced the evoked release only when the pretreatment interval was reduced from 15 min to 20 s Tubocurarine and hexamethonium concentration-dependently inhibited the end-organ response.
Naunyn-Schmiedeberg's Archives of Pharmacology  •  2004  |  View Paper
These nicotinic actions were completely reversed by dihydro-beta-erythroidine (DH-beta-E) or hexamethonium and reduced by D-tubocurarine.
Journal of neurophysiology  •  2002  |  View Paper
Increasing the concentration of hexamethonium produced potentiation of the neuromuscular blocking effect, this being greater with tubocurarine than with either pancuronium or alcuronium.
Low concentrations of hexamethonium antagonized the neuromuscular blocking effect of all three neuromuscular blocking drugs, less with tubocurarine than with the other two.
British journal of anaesthesia  •  1988  |  View Paper
The effectiveness of hexamethonium in blocking end‐plate currents was reduced in the presence of (+)‐tubocurarine , indicating that hexamethonium has a competitive blocking action on the receptors.
The Journal of physiology  •  1985  |  View Paper
1 The ability of hexamethonium (C6) to reverse the neuromuscular blocking action of tubocurarine (Tc) has been reinvestigated at the voltage clamped endplate of the omohyoid muscle of rat.
British journal of pharmacology  •  1984  |  View Paper
At present, it is shown that atropine and tubocurarine do not inhibit this activity of acetylcholine, but that it is inhibited by blocking the N1 receptor with hexamethonium.
Archivum immunologiae et therapiae experimentalis  •  1976  |  View Paper
Tubocurarine and hexamethonium presumably competitively antagonized acetylcholine (pA2 values, 7·3 and 5·8); lobeline was a noncompetitive antagonist (pD′2 value, 6·4).
The Journal of pharmacy and pharmacology  •  1976  |  View Paper
Equilibration with hexamethonium reduces the fraction excluded by tubocurarine and the transmitter now competes with hexamethonium for more receptors and produces a larger response.
British journal of pharmacology  •  1975  |  View Paper
At a [3H]acetyl-α-bungarotoxin … 0.875 µm, 1 µm d-tubocurarine inhibited binding 52%; 1 µm acetylcholine, 30%; 1 µm choline, 0%; 1 µm carbachol, … µm atropine, 0%; 1 mum gallamine, 33%; 1 µm decamethonium, 44%; 1 µm hexamethonium , 16%; 1 µm propanpheline, … 1 µm serotonin, 0%.
The Journal of biological chemistry  •  1972  |  View Paper