Possible Interaction: Tubocurarine and Decamethonium

“Even in man, the exceptional sensitivity of ocular and pharyngeal muscles to d-tubocurarine , relative to the other muscles, is less when the paralysis is induced with decamethonium.”

“If the ratio “sensitivity of muscle a/sensitivity of muscle b” is, with d-tubocurarine , raised above unity, then decamethonium will reduce it, often to far less than unity.”

“ D-tubocurarine prevented the action of the alkylating decamethonium (AD).”

“Klupp and associated were first to report a rise in KL in dogs following the administration of succinylcholine and decamethonium , and the antagonism of this hyperkalemic effect by the administration of d-tubocurarine.”

“At a [3H]acetyl-α-bungarotoxin … 0.875 µm, 1 µm d-tubocurarine inhibited binding 52%; 1 µm acetylcholine, 30%; 1 µm choline, 0%; 1 …, 38%; 1 µm atropine, 0%; 1 mum gallamine, 33%; 1 µm decamethonium , 44%; 1 µm hexamethonium, 16%; 1 …, 0%; and 1 µm serotonin, 0%.”

“ Tubocurarine reduced the uptake of labeled decamethonium in normal and in denervated muscles, and also in denervated muscles which had been depolarized by immersion in a solution which contained potassium methyl sulfate.”

“After complete block of neuromuscular transmission in extra- and intrafusal muscle fibers by tubocurarine , the spindle afferent activation by acetylcholine and decamethonium was almost or completely abolished, whereas that produced by succinylcholine, nicotine or tetramethylammonium was depreesed by approximately 50%.”

“The present investigations have shown that d-tubocurarine also reduces the uptake of decamethonium and of carbachol which have been labelled with tritium, and, in addition, the muscles have been sectioned so that a localized concentration of drug in the region of the nerve endings could be demonstrated.”

“ Decamethonium pretreatment decreases the amount of tubocurarine required to produce head-drop for more than 2 hours to an even greater extent than does pretreatment with tubocurarine itself; decamethonium is synergistic with a decamethonium pretreatment but for only 50 to 80 minutes.”

“The inhibitory action exercised by puromycin and nalidixic acid is of a mixed inhibition type, similar to the one seen when decamethonium and d-tubocurarine are used as inhibitory agents.”