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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Tryptophan
drug:
Valproic Acid
Research Papers that Mention the Interaction
“The most important findings of our study were that VPA administration produced a progressive and strong increase in the central concentrations of KYNA, KYN and TRP.”
The kynurenine pathway: A missing piece in the puzzle of valproate action?“This novel finding indicates that VPA , through the displacement of TRP from its protein-binding sites, could disturb the BCAA/AAA ratio, with central nervous system consequences, including the possible contribution to VPAs effects in affective disorders.”
“These results militate against the possibility that valproic acid alters the rate of tryptophan hydroxylation or the synthesis of 5-HT.”
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