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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Tryptophan
drug:
Urea
Research Papers that Mention the Interaction
“A significant negative correlation was found between TRP level and the concentration of urea and creatinine.”
“We found a significant negative correlation between TRP and serum concentration of urea and creatinine as well as a positive correlation with GFR.”
[Tryptophan and its metabolites in renal allograft recipients].“Injection with urea led to an apparent reduction in endogenous ammonia production, a significant decrease in the hepatic arginine content, and a significantly lower level of brain tryptophan in this lungfish.”
Effects of intra-peritoneal injection with NH4Cl, urea, or NH4Cl+urea on nitrogen excretion and metabolism in the African lungfish Protopterus dolloi.“Partially denaturing concentrations of urea eliminate the native-state quenching of intrinsic tryptophan fluorescence, from the single protein tryptophan, but the fluorescence emission spectrum is not red-shifted like the unfolded state, and the protein retains substantial secondary structure.”
“ Urea at low concentrations (1-4 M) quenches markedly the Trp 108 fluorescence around pH 7; the gamma max, however, remained unaltered.”
“Acrylamide quenching experiments further validated the above findings, as solvent accessibility of tryptophan residues increased with increase in GdHCl and urea concentration.”
Chemical- and Thermal-Induced Unfolding of Leishmania donovani Ribose-5-Phosphate Isomerase B: a Single-Tryptophan Protein
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