supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 5 years ago
supplement:
Tryptophan
drug:
Tetrahydrobiopterin
Research Papers that Mention the Interaction
“In contrast, both threo-phenylserine and tryptophan exhibit negligible activity in the presence of BH4 unless the enzyme has been activated.”
The interaction of aromatic amino acids with rat liver phenylalanine hydroxylase.“In addition, high concentrations of tryptophan inhibit the reaction in the presence of tetrahydrobiopterin , but not in the presence of the dimethylpterin.”
“Just as with the other pterin-dependent aromatic amino acid hydroxylases, the apparent Km of tryptophan hydroxylase for its amino acid substrate and for oxygen are markedly lower in the presence of tetrahydrobiopterin than they are in the presence of the cofactor analogue, dimethyltetrahydropterin.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback