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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Tryptophan
supplement:
Serum Albumin, Human
Research Papers that Mention the Interaction
“Circular dichroism and three-dimensional (3D) fluorescence showed that AB increased the hydrophobicity of Trp residue and the α-helix content of HSA by 1.99%.”
Unveiling the interaction mechanism of alogliptin benzoate with human serum albumin: Insights from spectroscopy, microcalorimetry, and molecular docking and molecular dynamics analyses.“The spectral changes observed in the binding systems we e all attributed to the alteration of the micro-environment around the tryptophan and tyrosine residues of HSA.”
“There was no significant change in the association equilibrium constants or specific activities for warfarin with HSA at pH 7.4 and 37 … were representative of those expected in pre-diabetes or diabetes, but a 4.7- to 5.8-fold increase in binding affinity for l-tryptophan … HSA ….”
“Based on the comparison between the effects of amino-acid fluids and L-tryptophan solutions, we confirmed that L-tryptophan in amino-acid fluids specifically inhibits drug binding to site II of HSA.”
“ D-Tryptophan had indirect interactions with the warfarin site of HSA but no interactions with the indole site.”
“The N --> F transition in HSA resulted in a more rigid environment for the tryptophan residue.”
Effect of ligand binding and conformational changes in proteins on oxygen quenching and fluorescence depolarization of tryptophan residues.
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