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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Tryptophan
drug:
Serotonin Agents
Research Papers that Mention the Interaction
“In rare cases, the "serotonin syndrome" occurs, the result of too much serotonin stimulation when Trp is combined with serotonin drugs.”
Effects and side effects associated with the non-nutritional use of tryptophan by humans.“ConclusionsThese findings provide evidence that TRP supplementation in women induces a positive bias in the processing of emotional material that is reminiscent of the actions of serotonergic antidepressants.”
“In conclusion, gestational tryptophan deprivation exerts adverse effects on the development of the 5‐HT system, particularly in the dorsal raphe, manifested by decreased numbers of serotonergic neurons as well as altered topography in this important nucleus.”
“Total numbers of serotonergic neurons at the dorsal raphe in the prenatal tryptophan deficient pups were reduced by 35%.”
Reduction of serotonergic neurons in the dorsal raphe due to chronic prenatal administration of a tryptophan-free diet“Abstract It is known that l-tryptophan stimulates serotonin synthesis in the brain and serotonergic neuronal activity.”
“The development of a potentially life-threatening serotonin syndrome or neuroleptic … syndrome (NMS)–like reactions has been reported with the use of serotonergic drugs , such as serotonin–norepinephrine reuptake inhibitors (SNRIs), selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants (TCAs), bupropion (Wellbutrin, GlaxoSmithKline), triptans, St. John’s wort, and tryptophan.”
Pharmaceutical approval update.
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