Possible Interaction: Tryptophan and Paroxetine

“ Paroxetine should not be coadministered with monoamine oxidase inhibitors or L-tryptophan.”

“2 Basal liver tryptophan pyrrolase activity was inhibited by paroxetine in vitro and after oral administration.”

“6 It is concluded that, in addition to inhibiting brain 5‐HT turnover, paroxetine also, in common with 20 other antidepressants, enhances 5‐HT synthesis by increasing brain tryptophan concentration secondarily to inhibition of liver tryptophan pyrrolase activity.”