Possible Interaction: Tryptophan and Naringenin

“Molecular docking studies revealed that both NG and NR bind in the close vicinity of Trp 62 and Trp 63 residues which is vital for the catalytic activity.”

“ Naringenin reversed altered levels of tryptophan , serotonin, 5‐Hydroxyindole acetic acid and kynurenine in hippocampus and cortex.”

“Analysis of gas chromatography-mass spectrometry (GC-MS) and fluorescence showed that relatively low concentrations of naringenin caused perturbations in the membrane fatty acid composition and the conformation of membrane proteins through changing the microenvironment of phenylalanine, tyrosine, and tryptophan residues.”