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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Tryptophan
drug:
Indoximod
Research Papers that Mention the Interaction
“In MLRs, 1-MT decreased tryptophan consumption, increased cell proliferation, glucose influx and lactate production, whereas it decreased tricarboxylic acid cycle activity.”
Inhibition of indoleamine 2,3-dioxygenase in mixed lymphocyte reaction affects glucose influx and enzymes involved in aerobic glycolysis and glutaminolysis in alloreactive T-cells.“Other analogs, such as methyltryptophan , are not enzymically activated but compete with tryptophan for enzyme activation.”
“ d-1mT treatment increased the plasma levels of Trp , without reducing the levels of Kyn, suggesting only a partial effect on IDO enzymatic activity.”
Combined Effect of Antiretroviral Therapy and Blockade of IDO in SIV-Infected Rhesus Macaques1“Peripheral injection of α‐methyltryptophan (400–1,600 μg/insect) caused a marked reduction in 5‐HT and tryptophan concentrations in cockroach cerebral ganglia without altering dopamine or octopamine concentrations.”
“ Indoximod is a small-molecule IDO pathway inhibitor that reverses the immunosuppressive effects of low tryptophan (Trp) and high kynurenine (Kyn) that result from IDO activity.”
Phase II trial of the IDO pathway inhibitor indoximod plus pembrolizumab for the treatment of patients with advanced melanoma
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