Possible Interaction: Trypsin and Ulinastatin

“ Urinary trypsin inhibitor (UTI) has a multipotent inhibitory effect on proteases such as trypsin , chymotrypsin, plasmin, human leukocyte elastase, or hyaluronidase.”

“These actions of ulinastatin seemed to be related to its inhibitory actions against serine proteases such as trypsin , alpha-chymotrypsin, plasmin, leukocyte elastase and leukocyte cathepsin G. Triamcinolone suppressed the IL-1 production more potently than ulinastatin and it also suppressed the IL-1 induced reduction of proteoglycan synthesis.”

“ Ulinastatin , is a broad-spectrum protease inhibitor purified from human urine, inhibits endogenous proteases such as trypsin , α-chymotrypsin, hyaluronidase, and plasmin.”

“ Trypsin , chymotrypsin and elastase were significantly inhibited by Pefabloc and UTI.”

“ UTI can inhibit proteases including trypsin , -chymotrypsin, plasmin, cathepsin G, and leukocyte elastase as well as proteases in the coagulation cascade.”

“A lack of reliable differences between the general and acid-stable activities in donors and in patients with nephritis is indicative of that TIU is the main inhibiter of trypsin in human urine.”

“ UTI is a Kunitz-type protease inhibitor which inhibits trypsin , plasmin and granulocyte elastase [3].”

“In the presence of heparin, inhibitory effects of ulinastatin on trypsin were enhanced, whereas its effects on chymotrypsin and elastase were attenuated.”

“After treatment by these enzymes, the urinary inhibitor has a lower molecular mass (Mr 26 000) but still inhibits trypsin.”

“This AS-PI strongly inhibited trypsin and to a lesser extent chymotrypsin, but exerted no inhibitory effect on plasmin.”