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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Trypsin and Rifamycin

supplement:

Trypsin

Research Papers that Mention the Interaction

Trypsinization of cells leads to a decrease both of specific binding and of binding affinity (affinity constant after 60 minutes of trypsinization 0.5 X 10(6) M-1 versus 1.5 X 10(6) M-1 in untreated control cells).
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme  •  1987  |  View Paper
It inhibits trypsin and thrombin with second-order rate constants (Kobs/[I]) of 2.6 x 10(5) M-1 s-1 and 1.0 x 10(5) M-1 s-1, respectively, showing a 130-fold and a 1250-fold rate enhancement over the corresponding diphenyl ester (4).
Bioorganic & medicinal chemistry  •  1998  |  View Paper
It is a peptide of M.W. 3020 of strong inhibitory activity (Ka = 8 x 10(11) M-1 ) against trypsin , showing high Gly content, six half-cystine residues, but devoid of histidine, threonine, tryptophan, and tyrosine residues.
International journal of peptide and protein research  •  1989  |  View Paper