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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Trypsin
drug:
Nafamostat
Research Papers that Mention the Interaction
“It was shown to act as a time-dependent competitive inhibitor, and the inhibition constants for the binding of Nafamostat to trypsin (i.e., Ki) and the overall inhibition constants (i.e., Ki*) were calculated to be 11.5 microM and 0.4+/-0.14 nM, respectively.”
“The product of the deacylation step, 4-guanidinobenzoic acid, showed … concentration of 200 microM. These data strongly suggest that while Nafamostat … trypsin , it is actually an extremely poor substrate, and that apparent inhibition is due to … a very stable acyl-enzyme intermediate, analogous to some other active site titrants.”
The kinetic and structural characterization of the reaction of nafamostat with bovine pancreatic trypsin.“ Nafamostat inhibited trypsin , plasmin, thrombin, pancreatic kallikrein, Clr and Cls more potently than gabexate and leupeptin.”
“Unlike aprotinin and urinastatin, nafamostat and gabexate inhibited alpha 2-macroglobulin bound trypsin as well as free trypsin to the same extent.”
[Comparative studies of nafamostat mesilate and various serine protease inhibitors in vitro].
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