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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Trypsin
drug:
Deoxycholate
Research Papers that Mention the Interaction
“ SDC increases the solubility of hydrophobic proteins, enhances the activity of trypsin , and improves the accessibility to trypsin of proteins denatured during the extraction process.”
Phase transfer surfactant-aided trypsin digestion for membrane proteome analysis.“However, the liver mitochondrial glycerophosphate acyltransferase was inhibited by trypsin in the presence of either 0.05% deoxycholate or 0.1% Triton X-100.”
Further distinguishing properties of mitochondrial and microsomal glycerophosphate acyltransferase and the transmembrane location of the mitochondrial enzyme.“Chymotrypsin and trypsin caused rapid and extensive degradation of the H-2Kk heavy chain when treatment was done in buffer containing deoxycholate , suggesting that the protein undergoes partial, but readily reversible, denaturation in this detergent.”
“The transfer decreased drastically by treatments of the medium with trypsin or detergents (dodecylsulfate or deoxycholate).”
“Extraction of these membranes by deoxycholate as well as treatment with phospholipase C (EC 3.1.4.3) or trypsin (EC 3.4.4.4) markedly reduced the adenylate cyclase activity in the absence or presence of NaF and norepinephrine.”
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