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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Trypsin
drug:
Aldesleukin
Research Papers that Mention the Interaction
“Dog IL-2 activity was significantly inhibited by heating at 65 degrees C, acidification under pH 4, alkalification over pH 10, and trypsin exposure.”
Characterization of dog interleukin-2 activity.“Digestion of TSF with trypsin completely destroyed the thrombocytopoietic-stimulating activity.”
“ Trypsin partially inhibited IL-2 activation of LAK activity enhanced by PheOMe.”
“Thus, IL-2 (MW 15,500) gains access to the active site of the alpha 2M-bound trypsin , resulting in a rapid loss of its biological activity.”
“In a highly purified mouse interferon preparation, the factor stimulating hydroxylase induction and the factor directing antiviral activity are inactivated by heating to 70 C or by treating with trypsin.”
Stimulation of Aryl Hydrocarbon Hydroxylase Induction in Cell Cultures by Interferon
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