“However, when HSA was fused at the C-terminus of dTMP , the bioactivity of dTMP-HSA was about half of that of HSA-dTMP.”
“In addition, fusion with HSA successfully prolonged dTMP half-life in mice.”
“In conclusion, these results suggested that HSA/dTMP fusion proteins might be potential drugs for thrombocytopenia and, when HSA was fused at the N-terminus of dTMP , the fusion protein had a higher activity.”