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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Trimethoprim, Sulfamethoxazole Drug Combination and Folate

Research Papers that Mention the Interaction

There have been additional barriers to the use of CTX prophylaxis in pregnant women, including concerns about the potential teratogenicity of CTX [8, 9] and the possible effects that CTX may have on folate metabolism that may contribute to low birth weight [10].
The Journal of infectious diseases  •  2006  |  View Paper
Based on these studies, in patients with either folate deficiency or increased folate requirements, trimethoprim‐sulfamethoxazole should be used with caution.
American journal of hematology  •  1986  |  View Paper
folate synthesis produces synergism and hence superior clinical activity, and that the two agents protect each other from the development of …-trimoxazole.4-6 Clinical trials have shown that in most urinary tract infections trimethoprim alone is as effective as co-trimoxazole and causes fewer side … of nucleic acids.
British medical journal  •  1980  |  View Paper