Possible Interaction: Trimetazidine and Calcium Supplement

“A number of experimental studies in this field have demonstrated that trimetazidine exerts direct anti-ischaemic effects, limiting calcium accumulation and acidosis, inflammation and oxygen-derived free radical production following reperfusion.”

“It has been reported that trimetazidine shows cardioprotective effects by decreasing the intracellular calcium accumulation by controlling the membrane ion gradients (3).”

“This was the first study to demonstrate that the antianginal drug trimetazidine selectively suppressed the activity of Ca 2 + channels activated by a drop in the Ca 2+ level in intracellular calcium stores in HL-60 human promyelocytes, the precursors of blood neutrophils and monocytes.”

“A number of experimental studies in this field have demonstrated that trimetazidine exerts direct anti-ischaemic effects, limiting calcium accumulation and acidosis, inflammation and oxygen-derived free radical production following reperfusion.”

“ Trimetazidine also inhibited the ciclosporine effects on calcium fluxes, i.e. calcium accumulation into the matrix and delay of efflux.”

“In voltage clamp experiment, trimetazidine at a concentration of 1.5 X 10(-4) M decreased the peak amplitude of calcium current by 40% (0.92 +/- 0.46 nA to 0.55 +/- 0.19 nA, mean +/- S.D., n = 5).”

“The effect on calcium current was rate-dependent, e.g., at 1 Hz, trimetazidine blocked a larger fraction of the calcium current than at 0.2 Hz.”

“These results suggest that TMZ has a dual action, namely 1) a blocking action of nicotinic transmissions and 2) a blocking action of Ca movement during the generation of action potentials.”

“ Trimetazidine slightly diminished the effect of strophanthin-G in high Ca , high K, and low K media as well as in Locke's solution.”