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Last Updated: 2 months ago

Possible Interaction: Trilostane and Adrenocorticotropic Hormone

Research Papers that Mention the Interaction

injection of 0.25 mg of ACTH was reduced from 398 nmol/l before trilostane to 287 nmol/l on 240 mg/day and to 291 nmol/l on 960 mg/day (P less than 0.01).
Clinical endocrinology  •  1982  |  View Paper
Trilostane also reduced stress-induced increase in plasma corticosterone and ACTH levels, showing direct effect on HPA axis activity.
Psychoneuroendocrinology  •  2009  |  View Paper
In another 10 dogs, there was a clear difference between the post ACTH cortisol concentrations observed four and 24 hours after the administration of trilostane.
Veterinary Record  •  2006  |  View Paper
When trilostane was added to inhibit de-novo steroidogenesis, under conditions in which the steroid secretory response to ACTH is completely inhibited, aldosterone and 18-OH-B secretion was still stimulated by trypsin although yields were lower.
The Journal of endocrinology  •  1992  |  View Paper
Concomitantly, maximal DHEA production documented in the presence of ACTH and trilostane was enhanced more than 200-fold, from 0.45 +/- 0.20 pmol in control rabbits to 147 +/- 67 pmol in cells from ACTH-treated animals.
Journal of steroid biochemistry  •  1986  |  View Paper
While trilostane completely abolished cortisol production in response to ACTH with concomitant enhancement in pregnenolone and 17-hydroxypregnenolone formation, the conversion of progesterone, 17-hydroxyprogesterone and 11-deoxycortisol into cortisol was not affected by the presence of the inhibitor.
Molecular and Cellular Endocrinology  •  1984  |  View Paper