Possible Interaction: Triiodothyronine and Vitamin E

“Although α-tocopherol (α-Toc) reportedly inhibits the hypocholesterolemic effect of T3 , there is no information about whether α-Toc influences the TG-lowering effect of T3 in vivo.”

“T3 are detected postprandially only after TRF supplementation and concentrations were significantly lower than α-T.ConclusionsBio-discrimination between vitamin E isomers in humans reduces the rate of T3 absorption and affects their incorporation into lipoproteins.”

“However, the T3 preparations used in those studies contained considerable amounts of tocopherol (Toc), which might affect the biological activity of T3.”

“Understanding T3 's antiangiogenic effects and interaction with Toc is important for developing medical applications.”

“Treatment of rats daily with T3 (8 μg/100 g BW) for 15 days resulted in an increase in heart weight to body weight ratio, which was ameliorated by antioxidants, melatonin (2 mg/100 g BW) or vitamin E (4 mg/100 g BW).”

“Under these conditions, the protein expression of the acute-phase proteins haptoglobin and beta-fibrinogen is significantly augmented, a change that is suppressed by pretreatment with alpha-tocopherol (100 mg/kg ip) or gadolinium chloride (10 mg/kg iv) before T3.”

“However, treatment with a mixture of 5 mg of alpha-T with 10 mg of T3 resulted in lesser inhibition (13%) of the liver HMGCR activity as compared to that obtained with 10 mg of T3.”

“T3 exhibited inhibitory effect on liver HMGCR and alpha-T attenuated the inhibitory effect of T3 on liver HMGCR.”