Possible Interaction: Triiodothyronine and Vitamin D

“ D3 terminates thyroid hormone action by inactivation of both T4 and T3 molecules.”

“In contrast, D3 catalyzes the inactivation of both T4 and T3 via inner-ring deiodination.”

“Furthermore, 25-hydroxyvitamin D was negatively correlated with the free thyroxine level (r = −0.1286, p = .0323) as well as the free triiodothyronine level (r = 0.1247, p = .0380).”

“Serum levels of 25-hydroxyvitamin D had a negative significant correlation with triiodothyronine ( T3 ) and T4, and a positive correlation with HDL.”

“Significants: Our findings indicate that D3 is expressed in hiPS‐CMs, and may decrease the intracellular T3 concentration, and may decrease the expression of cardiac genes such as MHC&agr; and &bgr;, SERCA, and PLB in hiPS‐CMs.”

“Women … cholecalciferol supplementation in month 7 … 25(OH)D at T3 than non-supplemented women (32.5 ± 11.4 versus 25.8 ± 11.4 ng/mL, p = <0.001) and … 25(OH)D in CB (17.2 ± 7.2 versus 15.5 ± 7.1 ng/mL, p = 0.004).”

“Results: Intakes of iron, B vitamins and vitamin D were around 20–60% higher in T3 compared with T1, with significant linear relationships observed for iron, thiamin, riboflavin and folate (T1 < T2 < T3).”

“Moreover, T3 increased MCT10 and LAT2 expression and T3 efflux from DCs but not T3 uptake, whereas it induced a robust induction of D3 with a parallel slight reduction in D2.”

“This has led to the hypotheses that D3 impacts injury tolerance by reducing local T3 signaling and contributes to the fall in serum triiodothyronine (T3) observed in up to 75% of sick patients (termed the low T3 syndrome).”

“ D3 also inactivates T3 to T2, terminating thyroid hormone action.”