Possible Interaction: Triiodothyronine and Tyrosine

“Urinary excretion of 3‐methylhistidine and plasma concentrations of valine, methionine, lysine, tyrosine , phenylalanine, isoleucine, leucine, and total essential and branched chain amino acids increased following administration of T3 , probably in part reflecting accelerated muscle proteolysis.”

“ T3 decreased tyrosine phosphorylation of JAK1, JAK2 and STAT3, and subsequently inhibited STAT3–DNA binding activity.”

“ Triiodothyronine caused twice the stimulation of casein and tyrosine phosphorylation on day 12, but had no effect on day 18.”

“Phenylalanine and tyrosine (but not the D-isomer of tryptophan or non-aromatic amino acids) also produced trans-acceleration for T3 uptake and T3 countertransport.”

“Whereas administration of l-triiodothyronine (10 mug/100 g/day) for 30 days to 120-day-old rats increased the levels of tyrosine by 23% and of tryptophan by 43%, no appreciable change was noted in tryptophan hydroxylase activity.”

“Exposure of developing rats to triiodothyronine increased the endogenous levels of striatal tyrosine and tyrosine hydroxylase as well as the concentration of dopamine in hypothalamus, pons-medulla, mid-brain, striatum and hippocampus.”

“In the presence of L-thyroxine and L-tyrosine the uptake of L-triiodothyronine is increased.”

“ L-tyrosine contributed to another vital rise in dose-dependence than control, in bodyweight, GSI, and testosterone, T3 , and T4.”

“ Tyrosine value was lowest (18.1 mg%) in T3.”

“Uptake of leucine, tyrosine , and tryptophan (10 M) was inhibited by the different iodothyronines (10 M), in particular T3.”

“Vice versa, uptake of 0.1 M T3 was almost completely blocked by coincubation with 100 M leucine, tryptophan, tyrosine , or phenylalanine.”