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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Trifluoperazine
supplement:
Gamma-Linolenic Acid
Research Papers that Mention the Interaction
“Calmodulin antagonists, chlorpromazine and trifluoperazine , inhibited free radical generation by human leukocytes in vitro induced by GLA , AA PMA (Phorbol myristate acetate), formyl-methionyl-leucyl-phenylalanine (FMLP) and lipopolysaccharide (LPS).”
Free radical generation in human leukocytes by CIS-unsaturated fatty acids is a calmodulin dependent process.“On the other hand, GLA formation from [1-14C]oleic acid was much less susceptile to TFP , which suggests that in this fungus Δ6 desaturation to GLA has at least two different pathways with different degrees of susceptibility to TFP.”
Modulation of fatty acid incorporation and desaturation by trifluoperazine in fungi
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