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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Trifluoperazine
supplement:
Adrenocorticotropic Hormone
Research Papers that Mention the Interaction
“It may be concluded that trifluoperazine alters ACTH stimulated mineralocorticoid secretion, while it does not influence angiotensin stimulated secretion.”
Influence of trifluoperazine on ACTH- or angiotensin-stimulated mineralocorticoid and glucocorticoid secretion in man.“In whole cells it was found that two responses (production of steroids and cAMP) to two stimulating agents ACTH and forskolin) were inhibited by trifluoperazine at concentrations consistent with those involved in binding of the inhibitor to pure calmodulin (10-25 microM).”
“With Y-1 plasma membranes it was found that trifluoperazine , pimozide, W-7, and calmodulin antibodies inhibited the increase in adenylate cyclase activity in response to ACTH , but not the cyclase responses to cholera toxin or forskolin.”
The role of calmodulin in the responses to adrenocorticotropin of plasma membranes from adrenal cells.“Penfluridol, pimozide, and trifluoperazine blocked the release of ACTH induced by CRF by 63%, 26%, and 0% respectively.”
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