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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Triclosan
supplement:
Epigallocatechin Gallate
Research Papers that Mention the Interaction
“ Triclosan lowered the k(6) of the EI(*) complex by 100 times, lowering the overall K(i)(*) of EGCG to 97.5+/-12.5 pM. The results support EGCG as a promising candidate for the development of tea catechin based antimalarial drugs.”
Epigallocatechin gallate is a slow-tight binding inhibitor of enoyl-ACP reductase from Plasmodium falciparum.“In the present study, we show, for the first time that epigallocatechin gallate (EGCG), a major component of green tea catechins, inhibits InhA, … of Mycobacterium tuberculosis with an IC50 of 17.4muM. EGCG interferes with the binding of NADH to InhA. We also demonstrate that EGCG increased … triclosan towards ….”
Combined effect of epigallocatechin gallate and triclosan on enoyl-ACP reductase of Mycobacterium tuberculosis.
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