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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
drug:
Triclosan
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“Here we show that exposure to triclosan disrupted membrane potential, prevented the calcium uptake-driven high-amplitude mitochondrial swelling, stimulated the respiration in the presence of complex I substrates, and suppressed the ADP-stimulated respiration in the presence of complex II substrate, succinate.”
Mechanism of triclosan toxicity: Mitochondrial dysfunction including complex II inhibition, superoxide release and uncoupling of oxidative phosphorylation.“ TCS potently impairs orthograde … retrograde signaling between L-type Ca2+ and RyR channels in skeletal muscle, and L-type Ca2+ entry in cardiac muscle, revealing a mechanism by which TCS weakens cardiac and skeletal muscle contractility in a manner that may negatively impact muscle health, especially in susceptible populations.”
“Dissociation of TCS and TCSi proceeds in parallel with barriers of ca.”
Pyrolysis of Triclosan (TCS) and its Chlorinated Derivatives.
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